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apalutamide will lessen the extent or outcome of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with medicines which have been CYP2C19 substrates can result in decrease exposure to those drugs.If a patient develops any of these reactions, the